Selective attention in Alzheimer's disease: CSF correlates of behavioral impairments.
نویسندگان
چکیده
CSF levels of HVA, 5-HIAA, and free MHPG, the major metabolites of dopamine, serotonin, and norepinephrine respectively, were measured in 22 patients with AD. These 22 patients were also administered tests of picture-recognition and attentional focusing as part of an earlier experiment. A significant association between deficits in attentional focusing and reduced levels of free MHPG in CSF was noted. These results suggest that behavioral measures can identify patients with noradrenergic involvement.
منابع مشابه
P 62: Markers of Neuroinflammation Related to Alzheimer\'s Disease Pathology in the Elderly
Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of dementia. Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. In vitro and animal studies have linked neuroinflammation to Alzheimer's disease (AD) pathology. Studies on marke...
متن کاملNeural correlates of empathic impairment in the behavioral variant of frontotemporal dementia.
OBJECTIVE Loss of empathy is a symptom of the behavioral variant of frontotemporal dementia (bvFTD), constituting a clue for early diagnosis. In this study, we directly compared two empathy components (intention attribution [IA] and emotion attribution [EA]), correlating them with possible specific patterns of gray-matter density reduction within the mentalizing network. METHODS We evaluated ...
متن کاملThe effect of cognitive therapy on cognition in elderly people with Alzheimer's disease: A review article
Introduction and purpose: Elderly people often face cognitive problems due to the aging process. Decreased ability in cognitive functions leads to impaired performance in daily activities of judgment, attention, and awareness. Therefore, this study investigates different cognitive therapies on cognition in elderly people with Alzheimer's disease. Materials and Methods: Prisma method was used i...
متن کاملNormobaric hyperoxia preconditioning attenuates streptozotocin - induced impairments in spatial learning
Introduction: A large body of evidence points to oxidative stress as prime candidate mediating the behavioral impairments and memory deficits in Alzheimer's disease (AD). It has been demonstrated that hyperoxia preconditioning activates complex endogenous neuroprotective mechanisms including an increase in capacity of antioxidant defence mechanisms. The aim of this study was to investigate the ...
متن کاملProspective Memory Impairments in Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia: Clinical and Neural Correlates.
BACKGROUND Prospective memory (PM) refers to a future-oriented form of memory in which the individual must remember to execute an intended action either at a future point in time (Time-based) or in response to a specific event (Event-based). Lapses in PM are commonly exhibited in neurodegenerative disorders including Alzheimer's disease (AD) and frontotemporal dementia (FTD), however, the neuro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Neuropsychologia
دوره 26 6 شماره
صفحات -
تاریخ انتشار 1988